We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Read More
9
CoQ10 reduces heart cell death
Cardioprotective Effect of Coenzyme Q on Apoptotic Myocardial Cell Death by Regulation of Bcl-2 Gene Expression.
We explored how coenzyme Q10 (CoQ10) impacts heart damage caused by a lack of blood flow, known as ischemia, followed by the restoration of blood flow, which can lead to further injury. In our study, we utilized a rat model divided into three groups: a control group that did not undergo any induced heart injury, a group that experienced ischemia and reperfusion, and a group pre-treated with CoQ10 before the injury.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
Read More
8
CoQ10 improves heart recovery post-MI
Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway.
We embarked on a study to explore how Coenzyme Q10 (CoQ10) might aid in recovering cardiac function following a heart attack, or myocardial infarction (MI). By measuring the effects of CoQ10 on both patients and mice, we aimed to understand its role in promoting heart health post-MI.
Our research included a comparison between MI patients receiving CoQ10 and those who did not. We conducted evaluations at one and three months after treatments to assess heart function. In the animal model, we observed that mice receiving CoQ10 showed improved heart performance compared to those that did not, suggesting significant benefits for heart recovery.
An interesting finding was that CoQ10 appears to inhibit certain inflammatory responses in the heart, specifically by affecting a pathway associated with macrophages, which are immune cells that can contribute to inflammation. By preventing these macrophages from accumulating in the heart and activating pro-inflammatory signals, CoQ10 may help to reduce the harmful effects of inflammation following a heart attack.
Overall, our results indicate that CoQ10 can be a valuable addition to treatment plans for individuals recovering from heart attacks, potentially speeding up recovery and improving heart function.
Read More
Most Useful Reviews
9
Lowering cholesterol
44 people found this helpful
Red yeast rice is often used by those unable to tolerate statins. It may also lower coenzyme Q10 levels, so supplementation with ubiquinol is advisable. I took red yeast rice for my cholesterol, which was almost three times higher than normal. After two months, my cholesterol levels dropped significantly, although the results might not be immediate. I feel hopeful and will continue with this supplement, planning to order more. Retesting will provide more insight into its effectiveness in preventing heart attack.
Read More
9
Significant cholesterol drop
6 people found this helpful
Red yeast rice effectively lowers bad cholesterol (LDL) and triglycerides while increasing good cholesterol (HDL). It helps with weight management and maintains healthy liver enzymes. In studies, participants using red fermented rice reported lower cholesterol without disturbing liver function. My total cholesterol reduced significantly by 25% while taking this product along with Omega 3 and berberine, which is outstanding.
Read More
9
Natural statin effect
2 people found this helpful
Red Yeast Rice acts similarly to statins in a natural way. It’s essential to supplement with CoQ10 since it blocks its natural production. This supplement already includes it, which is great. I took 1 twice daily, and the jar lasts for two months.
We explored the connection between acute heart attacks and potential liver and kidney complications, specifically focusing on the role of coenzyme Q10 (Q10). In our study, we examined male rats divided into groups—some receiving normal saline and others pretreated with Q10 for 28 days, followed by an induced heart attack using isoprenaline (ISO).
Our findings revealed that ISO administration increased oxidative stress and negatively affected liver and kidney health. However, those pretreated with Q10 showed notable protection against both biochemical and tissue changes linked to these complications. We observed significantly improved antioxidant levels and a reduction in harmful liver and kidney enzymes. Furthermore, the histopathological examination indicated less severe damage in the tissues of the rats given Q10 compared to those that received ISO alone.
Overall, this study suggests that coenzyme Q10 may help shield the liver and kidneys during recovery from a heart attack by counteracting oxidative stress and reducing fibrotic changes. This finding highlights the potential of Q10 as a supportive treatment during critical cardiac events.
Read More
9
CoQ10 offers protection post-MI
Synergetic EGCG and coenzyme Q10 DSPC liposome nanoparticles protect against myocardial infarction.
We explored the effectiveness of coenzyme Q10 (CoQ10) when used alongside epigallocatechin gallate (EGCG) in protecting heart cells after a myocardial infarction (MI). The study focused on liposome nanoparticles made with distearyl phosphatidylcholine (DSPC) to deliver these compounds effectively. By doing this, we aimed to see whether this combination could reduce oxidative stress and cell death in heart tissue.
Our results showed that these liposome nanoparticles, referred to as CE-LNPs, were well-tolerated by cells and were taken up efficiently by macrophages. These nanoparticles successfully lowered harmful reactive oxygen species (ROS) in heart cells under stress, lessened cell death, and helped maintain the health and growth of those cells. We validated these positive outcomes through various tests that confirm their anti-apoptotic properties, or their ability to prevent cell death.
In a mouse model of MI, the CE-LNPs significantly reduced scar tissue formation, aiding in cardiac recovery and enhancing heart function. These findings suggest that using CoQ10 in conjunction with EGCG within DSPC liposomes can provide protective effects against heart damage following a heart attack. However, since these two were tested together, we note that isolating the specific impact of CoQ10 alone remains challenging. Overall, we have evidence of a promising approach for heart protection using these formulations.
Read More
9
Coenzyme Q10 aids heart recovery
Coenzyme Q10 Modulates Remodeling Possibly by Decreasing Angiotensin-Converting Enzyme in Patients with Acute Coronary Syndrome.
We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Read More
9
CoQ10 reduces heart cell death
Cardioprotective Effect of Coenzyme Q on Apoptotic Myocardial Cell Death by Regulation of Bcl-2 Gene Expression.
We explored how coenzyme Q10 (CoQ10) impacts heart damage caused by a lack of blood flow, known as ischemia, followed by the restoration of blood flow, which can lead to further injury. In our study, we utilized a rat model divided into three groups: a control group that did not undergo any induced heart injury, a group that experienced ischemia and reperfusion, and a group pre-treated with CoQ10 before the injury.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
Read More
8
Coenzyme Q10 may aid heart recovery
Angiotensin converting enzyme inhibitor and coenzyme Q10 as adjunctive treatment for patients with ventricular septal rupture following late onset myocardial infarction: a case report.
We explored the effects of coenzyme Q10 in conjunction with lisinopril as a treatment for patients suffering from ventricular septal rupture (VSR) following a heart attack. This rare complication can lead to severe issues and is typically treated with surgery. However, not all hospitals have the facilities for immediate surgical intervention, making alternative treatments essential.
In a recent case, a 74-year-old woman was admitted with late-onset myocardial infarction and subsequently diagnosed with VSR and pulmonary hypertension. As her condition worsened, traditional treatment with vasopressors was initiated. To enhance her recovery, doctors introduced lisinopril and coenzyme Q10, which reportedly supported her heart function and stability over three months.
While the findings suggest that the combination of these two treatments could improve energy production and tissue healing, it is crucial to note the difficulty in isolating the effects of coenzyme Q10 alone from lisinopril. This limitation makes it hard to draw definitive conclusions about how effective coenzyme Q10 is on its own for managing heart attack complications.
Red yeast rice is often used by those unable to tolerate statins. It may also lower coenzyme Q10 levels, so supplementation with ubiquinol is advisable. I took red yeast rice for my cholesterol, which was almost three times higher than normal. After two months, my cholesterol levels dropped significantly, although the results might not be immediate. I feel hopeful and will continue with this supplement, planning to order more. Retesting will provide more insight into its effectiveness in preventing heart attack.
Read More
9
Significant cholesterol drop
6 people found this helpful
Red yeast rice effectively lowers bad cholesterol (LDL) and triglycerides while increasing good cholesterol (HDL). It helps with weight management and maintains healthy liver enzymes. In studies, participants using red fermented rice reported lower cholesterol without disturbing liver function. My total cholesterol reduced significantly by 25% while taking this product along with Omega 3 and berberine, which is outstanding.
Read More
9
Natural statin effect
2 people found this helpful
Red Yeast Rice acts similarly to statins in a natural way. It’s essential to supplement with CoQ10 since it blocks its natural production. This supplement already includes it, which is great. I took 1 twice daily, and the jar lasts for two months.
Read More
7.5
Heart health support
2 people found this helpful
I highly recommend Jarrow Formulas Vegan Red Yeast Rice + Co-Q10! This exceptional supplement combines red yeast rice and Co-Q10, both renowned for supporting heart health. The veggie capsules are easy to swallow, and after consistent use, I’ve noticed improvements in my heart health and energy. Excellent value for money!
Read More
7.5
Lowered cholesterol levels
19 people found this helpful
I’m really enthusiastic about this product. It slows down the ageing process; I see no signs of fatigue. More importantly, I’ve had high cholesterol for years, leading to high blood pressure and heart attack symptoms. After taking this product, my cholesterol dropped from 8 to 6.8, which I find impressive. It contains CO Q10, essential for heart health as we age. I've already ordered another jar to keep my cholesterol down naturally.
A heart attack, also known as myocardial infarction, occurs when blood flow to a part of the heart is blocked, often by a blood clot. This interruption can damage or destroy part of the heart muscle, leading to serious health complications or death if not treated promptly. Common symptoms include chest pain, shortness of breath, nausea, and lightheadedness. Risk factors include high blood pressure, high cholesterol, smoking, diabetes, and a sedentary lifestyle.
Preventing a heart attack largely revolves around maintaining a heart-healthy lifestyle. Regular exercise, a balanced diet rich in fruits, vegetables, whole grains, and lean proteins, along with managing stress, can significantly lower the risk. Furthermore, understanding your personal risk factors and engaging with healthcare professionals for regular check-ups can be crucial in both prevention and early detection. If you suspect someone is having a heart attack, it's important to call emergency services immediately, as timely treatment is vital for survival and recovery.
Red yeast rice is a traditional Chinese food and herbal supplement made by fermenting rice with a specific type of mold called Monascus purpureus. This fermentation process gives the rice its distinctive red color, as well as its potential health benefits. Historically, it has been used in Asian cuisine as a coloring agent and flavor enhancer, but it has gained popularity in the wellness community mainly for its cholesterol-lowering effects. The active compounds in red yeast rice include monacolins, particularly monacolin K, which is chemically similar to the active ingredient in statin medications used to manage cholesterol levels.
Numerous studies suggest that red yeast rice may effectively reduce total cholesterol and LDL (commonly referred to as "bad" cholesterol) levels. However, results can vary based on the dosage and specific product formulation, as the amount of active compounds in supplements can differ significantly. As with any supplement, it’s essential to consult with a healthcare professional before adding red yeast rice to your regimen, especially for individuals with existing health conditions or those taking medication, as it may interact with other treatments. Overall, while red yeast rice could offer benefits for heart health, it should be approached with consideration and care.
Red yeast rice is a traditional Chinese dietary staple that has gained popularity as a supplement purported to support heart health, particularly due to its ability to lower cholesterol levels. It contains naturally occurring compounds called monacolins, with monacolin K being similar to the active ingredient in prescription statin medications. Some studies suggest that red yeast rice can help reduce total cholesterol and LDL (bad cholesterol) levels, which may, in turn, contribute to a lower risk of heart disease and potentially heart attacks.
However, it is essential to approach red yeast rice with caution. Not all supplements are created equal, and the potency and purity can vary significantly between brands. Additionally, individuals with underlying health conditions or those taking cholesterol-lowering medications should consult a healthcare professional before adding red yeast rice to their regimen. While it may offer benefits for heart health, it is not a guaranteed solution for preventing heart attacks and should be considered a complementary approach to a heart-healthy lifestyle that includes a balanced diet and regular exercise.
Based on user reviews, the timeframe for noticing results from taking red yeast rice can vary. Some users report experiencing significant improvements in their cholesterol levels after consistent use. For instance, one reviewer noted a reduction in cholesterol levels after two months of taking the supplement (Read Review). Another user experienced a notable drop in cholesterol from 8 to 6.8 after starting the supplement, indicating a fairly quick response to its cholesterol-lowering effects (Read Review).
However, some reviewers suggest that more significant results may take additional time to manifest. One individual mentioned seeing only slight improvements in their mother’s blood pressure and heart rate, implying that longer usage might be necessary to achieve more substantial benefits (Read Review). Overall, while many users report improvements in heart health and cholesterol levels within a couple of months, individual experiences may differ, and continuous use appears essential for optimal results.
Coenzyme Q10 (CoQ10) has garnered attention for its potential role in supporting heart health, particularly in the context of heart attack recovery. Multiple studies have indicated that CoQ10 may provide protective effects against oxidative stress, which is known to exacerbate cardiac damage following ischemic events. For instance, research has shown that CoQ10 supplementation can improve heart function and promote recovery in patients who have suffered a myocardial infarction (MI), as evidenced by enhanced antioxidant levels and reduced markers of oxidative damage ([8]). Another study also observed improved cardiac performance in both animal and human models, indicating that CoQ10 could mitigate inflammatory responses post-MI ([3]).
However, while the preliminary evidence is promising, it's noteworthy that many studies investigate CoQ10 in conjunction with other treatments, making it challenging to isolate its specific effects ([2]). Additionally, there remains a need for further research to establish definitive conclusions about its efficacy tailored specifically for heart attack recovery, given the varied results seen in different patient populations ([12]). Overall, CoQ10 is supported by scientific research as a potentially beneficial supplement for heart attack recovery, yet individual results may vary, reinforcing the importance of consultation with healthcare providers for personalized treatment plans.
Based on user reviews, many individuals report significant improvements in their cholesterol levels and overall heart health after using red yeast rice. For instance, one user noted a remarkable 25% reduction in total cholesterol while combining the supplement with Omega-3 and berberine (Read Review). Others have shared experiences of decreased cholesterol levels after consistent use, with one individual witnessing a drop from 8 to 6.8, attributing this improvement to the supplement's blend of red yeast rice and CoQ10, which is known for its heart-supporting properties (Read Review).
Users have also reported improvements in energy levels and reduced symptoms related to heart health, such as fewer heart palpitations (Read Review) and enhanced circulation, which helped alleviate cold extremities (Read Review, Read Review). However, it is important to note that individual results can vary dramatically, with some users reporting only slight improvements over longer periods (Read Review), emphasizing that continuous use may be necessary for optimal benefits.
Users report that combining red yeast rice with other supplements may enhance its effectiveness in managing heart health and cholesterol levels. For example, one reviewer experienced a notable 25% reduction in total cholesterol while taking red yeast rice alongside Omega-3 and berberine, highlighting the potential benefits of such combinations for heart health (Read Review). Another user emphasized the importance of supplementing with CoQ10 due to its complementary relationship with red yeast rice, as it may counterbalance the reduction of CoQ10 levels caused by red yeast products (Read Review).
Moreover, several users noted that the addition of CoQ10 in their red yeast rice supplements contributed positively to their overall heart health and energy levels, with one reviewer specifically stating that they felt better overall, even if they did not find the product very effective in isolation (Read Review). Although many users reported positive outcomes from these combinations, results can vary, and some individuals noted that it may take time to observe significant benefits. Continuous use, paired with other supplements, seems to be a common recommendation among users for optimal results in heart health management and cholesterol reduction.
Users have shared varied experiences regarding the right dose of Red Yeast Rice for managing heart health, particularly in lowering cholesterol levels. Many reported positive outcomes with doses of 1 or 2 capsules taken twice daily, noting a significant reduction in cholesterol over a period of time. For instance, one reviewer mentioned a 25% decrease in total cholesterol while combining Red Yeast Rice with Omega 3 and berberine, highlighting that it can effectively lower bad cholesterol (LDL) while boosting good cholesterol (HDL) Read Review. Other users confirmed improvement in their cholesterol metrics after consistent use, emphasizing the importance of CoQ10 supplementation alongside Red Yeast Rice Read Review.
Despite the positive feedback on effectiveness, some users indicated a need for patience, as results may take time to manifest fully Read Review. Several noted that, while individual results may vary, beginning with a standard dosage of 1 to 2 capsules daily and assessing personal response seemed to be a common approach. Overall, users appear to support this supplement for improving heart health, although they recommend monitoring cholesterol levels regularly to gauge effectiveness Read Review.
9
Lowering cholesterol
44 people found this helpful
Red yeast rice is often used by those unable to tolerate statins. It may also lower coenzyme Q10 levels, so supplementation with ubiquinol is advisable. I took red yeast rice for my cholesterol, which was almost three times higher than normal. After two months, my cholesterol levels dropped significantly, although the results might not be immediate. I feel hopeful and will continue with this supplement, planning to order more. Retesting will provide more insight into its effectiveness in preventing heart attack.
7.5
Lowered cholesterol levels
19 people found this helpful
I’m really enthusiastic about this product. It slows down the ageing process; I see no signs of fatigue. More importantly, I’ve had high cholesterol for years, leading to high blood pressure and heart attack symptoms. After taking this product, my cholesterol dropped from 8 to 6.8, which I find impressive. It contains CO Q10, essential for heart health as we age. I've already ordered another jar to keep my cholesterol down naturally.
6
Mild effect noted
2 people found this helpful
My mother is taking this product and has observed a slight effect. Her blood pressure has improved a little, and her heart rate feels better than before. It seems to require a longer time to see more significant results.
9
Significant cholesterol drop
6 people found this helpful
Red yeast rice effectively lowers bad cholesterol (LDL) and triglycerides while increasing good cholesterol (HDL). It helps with weight management and maintains healthy liver enzymes. In studies, participants using red fermented rice reported lower cholesterol without disturbing liver function. My total cholesterol reduced significantly by 25% while taking this product along with Omega 3 and berberine, which is outstanding.
7.5
Reduced heart palpitations
After using this supplement for a while, I noticed fewer heart palpitations. The overall effect, however, remains to be confirmed.
7.5
Circulation improvement
1 people found this helpful
This dietary supplement was prescribed due to high cholesterol and complaints of cold limbs. After starting it, my blood circulation improved. My extremities stopped feeling cold, and my heart seems to beat more steadily, with tests showing lower cholesterol. It's a reliable supplement.
7.5
Improved blood circulation
9 people found this helpful
This dietary supplement was prescribed to help with high cholesterol and cold extremities. Since taking it, my blood circulation has normalised; my fingers and toes no longer feel cold. My heart now works more evenly, and my tests indicate a decrease in cholesterol levels. It’s a working dietary supplement.
9
Natural statin effect
2 people found this helpful
Red Yeast Rice acts similarly to statins in a natural way. It’s essential to supplement with CoQ10 since it blocks its natural production. This supplement already includes it, which is great. I took 1 twice daily, and the jar lasts for two months.
6
Limited effectiveness
I take Jarrow Formulas, Red Yeast + Co-Q10 to support my heart health. While I don't find it very effective, I still feel better overall.
8
CoQ10 improves heart recovery markers
Effects of coenzyme Q10 supplementation on oxidative stress biomarkers following reperfusion in STEMI patients undergoing primary percutaneous coronary intervention.
We conducted a study to see how coenzyme Q10 (CoQ10) might help patients recovering from a heart attack, specifically those experiencing ST-elevation myocardial infarction (STEMI) and undergoing primary percutaneous coronary intervention (PPCI). In this randomized trial, seventy patients were split into two groups: one received standard treatments along with CoQ10, while the other received standard treatment plus a placebo.
We measured various markers in the patients' blood to assess oxidative stress—this refers to the imbalance between antioxidants and harmful reactive molecules in the body. While the changes in these markers at 6 and 24 hours were similar for both groups, we saw significant benefits for the CoQ10 group at the 72-hour mark. Specifically, those taking CoQ10 had higher levels of protective antioxidants like superoxide dismutase and catalase, and lower levels of the harmful substance malondialdehyde.
Overall, this suggests that CoQ10 could play a valuable role in reducing oxidative stress and may help with heart muscle recovery after reperfusion, the process following a heart attack when blood supply is restored. However, it's worth noting that the plasma activity of another antioxidant, glutathione peroxidase, didn’t show significant differences between the two groups.
8
CoQ10 improves heart recovery post-MI
Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway.
We embarked on a study to explore how Coenzyme Q10 (CoQ10) might aid in recovering cardiac function following a heart attack, or myocardial infarction (MI). By measuring the effects of CoQ10 on both patients and mice, we aimed to understand its role in promoting heart health post-MI.
Our research included a comparison between MI patients receiving CoQ10 and those who did not. We conducted evaluations at one and three months after treatments to assess heart function. In the animal model, we observed that mice receiving CoQ10 showed improved heart performance compared to those that did not, suggesting significant benefits for heart recovery.
An interesting finding was that CoQ10 appears to inhibit certain inflammatory responses in the heart, specifically by affecting a pathway associated with macrophages, which are immune cells that can contribute to inflammation. By preventing these macrophages from accumulating in the heart and activating pro-inflammatory signals, CoQ10 may help to reduce the harmful effects of inflammation following a heart attack.
Overall, our results indicate that CoQ10 can be a valuable addition to treatment plans for individuals recovering from heart attacks, potentially speeding up recovery and improving heart function.
8
Coenzyme Q10 may aid heart recovery
Angiotensin converting enzyme inhibitor and coenzyme Q10 as adjunctive treatment for patients with ventricular septal rupture following late onset myocardial infarction: a case report.
We explored the effects of coenzyme Q10 in conjunction with lisinopril as a treatment for patients suffering from ventricular septal rupture (VSR) following a heart attack. This rare complication can lead to severe issues and is typically treated with surgery. However, not all hospitals have the facilities for immediate surgical intervention, making alternative treatments essential.
In a recent case, a 74-year-old woman was admitted with late-onset myocardial infarction and subsequently diagnosed with VSR and pulmonary hypertension. As her condition worsened, traditional treatment with vasopressors was initiated. To enhance her recovery, doctors introduced lisinopril and coenzyme Q10, which reportedly supported her heart function and stability over three months.
While the findings suggest that the combination of these two treatments could improve energy production and tissue healing, it is crucial to note the difficulty in isolating the effects of coenzyme Q10 alone from lisinopril. This limitation makes it hard to draw definitive conclusions about how effective coenzyme Q10 is on its own for managing heart attack complications.
7
CoQ10 shows promise in heart health
Coenzyme Q: Clinical Applications in Cardiovascular Diseases.
We explored the potential effects of coenzyme Q10 (CoQ10) supplementation on heart attacks and related cardiovascular issues. This supplement, known for its role in energy production and its antioxidant properties, has generated interest as a possible support in managing heart health.
Several randomized clinical trials have looked into the impact of CoQ10 on heart attack patients and those dealing with conditions like heart failure and hypertension. These studies have noted promising decreases in inflammatory markers and oxidative stress, which are crucial factors in heart disease.
However, while the results are encouraging, many studies included diverse cardiovascular issues rather than focusing solely on heart attacks. More extensive research with larger groups of patients will be necessary to claim CoQ10's effectiveness specifically for heart attack treatment. It's vital to continue evaluating this supplement's role while we await further scientific findings.
References
Chidebe EO, Moke EG, Asiwe JN, Ben-Azu B, Demaki WE, et al. Therapeutic effect of coenzyme-Q10 pretreatment on isoprenaline-induced cardiogenic hepatorenal complications in rats. Int J Physiol Pathophysiol Pharmacol. 2024;16:126. 10.62347/PFXZ9903
Intan RE, Balti DR, Nugraha RA, Alkaff FF, Salamah S, et al. Angiotensin converting enzyme inhibitor and coenzyme Q10 as adjunctive treatment for patients with ventricular septal rupture following late onset myocardial infarction: a case report. J Pak Med Assoc. 2024;74:S81. 10.47391/JPMA.S6-ACSA-16
Pan W, Zhou G, Hu M, Li G, Zhang M, et al. Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway. BMC Cardiovasc Disord. 2024;24:76. 10.1186/s12872-024-03729-x
Lei W, Yang J, Wang J, Xiao Z, Zhou P, et al. Synergetic EGCG and coenzyme Q10 DSPC liposome nanoparticles protect against myocardial infarction. Biomater Sci. 2023;11:6862. 10.1039/d3bm00857f
Ahmadimoghaddam D, Talebi SS, Rahmani A, Zamanirafe M, Parvaneh E, et al. Prevention of contrast induced-acute kidney injury using coenzyme Q10 in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Eur J Clin Pharmacol. 2023;79:1341. 10.1007/s00228-023-03546-9
Mokhtari B, Badalzadeh R. Mitochondria-targeted combination treatment strategy counteracts myocardial reperfusion injury of aged rats by modulating autophagy and inflammatory response. Mol Biol Rep. 2023;50:3973. 10.1007/s11033-023-08318-3
Li D, Zhang G, Wang Z, Guo J, Liu Y, et al. Idebenone attenuates ferroptosis by inhibiting excessive autophagy via the ROS-AMPK-mTOR pathway to preserve cardiac function after myocardial infarction. Eur J Pharmacol. 2023;943:175569. 10.1016/j.ejphar.2023.175569
Yazdi A, Shirmohammadi K, Parvaneh E, Entezari-Maleki T, Hosseini SK, et al. Effects of coenzyme Q10 supplementation on oxidative stress biomarkers following reperfusion in STEMI patients undergoing primary percutaneous coronary intervention. J Cardiovasc Thorac Res. 2023;15:250. 10.34172/jcvtr.2023.31817
An P, Wan S, Luo Y, Luo J, Zhang X, et al. Micronutrient Supplementation to Reduce Cardiovascular Risk. J Am Coll Cardiol. 2022;80:2269. 10.1016/j.jacc.2022.09.048
Shah IA, Memon M, Ansari S, Kumar R, Chandio SA, et al. Role of Coenzyme Q10 in Prophylaxis of Myocardial Infarction. Cureus. 2021;13:e13137. 10.7759/cureus.13137
Fontaine F, Legallois D, Créveuil C, Chtourou M, Coulbault L, et al. Is plasma concentration of coenzyme Q10 a predictive marker for left ventricular remodelling after revascularization for ST-segment elevation myocardial infarction?. Ann Clin Biochem. 2021;58:327. 10.1177/00045632211001100
Martelli A, Testai L, Colletti A, Cicero AFG. Coenzyme Q: Clinical Applications in Cardiovascular Diseases. Antioxidants (Basel). 2020;9. 10.3390/antiox9040341
Singh RB, Fedacko J, Mojto V, Pella D. Coenzyme Q10 Modulates Remodeling Possibly by Decreasing Angiotensin-Converting Enzyme in Patients with Acute Coronary Syndrome. Antioxidants (Basel). 2018;7. 10.3390/antiox7080099
Khan NA, Abid M, Ahmad A, Abuzinadah MF, Basheikh M, et al. Cardioprotective Effect of Coenzyme Q on Apoptotic Myocardial Cell Death by Regulation of Bcl-2 Gene Expression. J Pharmacol Pharmacother. 2017;8:122. 10.4103/jpp.JPP_47_17
Sharifi MH, Eftekhari MH, Ostovan MA, Rezaianazadeh A. Effects of a therapeutic lifestyle change diet and supplementation with Q10 plus L-carnitine on quality of life in patients with myocardial infarction: A randomized clinical trial. J Cardiovasc Thorac Res. 2017;9:21. 10.15171/jcvtr.2017.03
Mirhashemi SM, Najafi V, Raygan F, Asemi Z. The effects of coenzyme Q10 supplementation on cardiometabolic markers in overweight type 2 diabetic patients with stable myocardial infarction: A randomized, double-blind, placebo-controlled trial. ARYA Atheroscler. 2016;12:158.